Senior or Principal Scientist


The successful candidate will conduct experiments and lead a small team in planning and executing experiments. This position will be on-site in our R&D laboratory in Charlottesville, VA.


ZielBio, Inc. is a clinical-stage biotechnology company that identifies novel high-value disease targets and develops therapeutic interventions to improve patient outcomes. ZielBio has a rich pipeline with lead candidate ZB131 currently in the clinic. ZB131 is a proprietary humanized monoclonal antibody against cell surface plectin (CSP), a target that is highly expressed on the plasma membrane of multiple types of cancer cells, including ovarian, pancreatic, cholangiocarcinoma, lung, and colorectal.

Key Responsibilities

  • Work with scientific leads to develop strategies for R&D programs
  • Plan and design experiments in support of R&D program strategies
  • Conduct experiments and manage a subteam of 1-2 laboratory personnel
  • Managing and balancing workload, prioritizing team members’ time, training, and onboarding
  • Overseeing work quality and pace of team members, providing feedback and coaching as needed
  • Analysis, interpretation, and recording of experimental data
  • Interfacing with CROs as needed to provide input on study design
  • Present study design and results at project team and other ZielBio/internal meetings. Present key findings at external conferences
  • Participate in preparing relevant scientific documents such as regulatory applications or manuscripts

Experience and Qualifications

  • Ph.D. in Biomedical Engineering or related field with 4+ years of post-Ph.D. experience (M.S. with equivalent experience will be considered)
  • Minimum of 5 years of hands-on experience with molecular biology and cell-based assays
  • Minimum of 2 years of experience supervising and managing a small team; industry experience is a plus
  • Solid background in oncology; experience with ADC is a plus
  • Track record of successfully designing and conducting experiments
  • Excellent communication and interpersonal skills, time/resource management, attention to detail, and proven success working in matrix environments

Job Type



Charlottesville, VA (On-site)

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